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References Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity (OASIS 4) , New England Journal of Medicine, 2025 [Accessed 20 April 2026] Oral Semaglutide 50 mg Taken Once Per Day in Adults with Overweight or Obesity (OASIS 1) , The Lancet, 2023 [Accessed 20 April 2026] Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1) , New England Journal of Medicine, 2021 [Accessed 20 April 2026] Once-Weekly Semaglutide 7.2 mg in Adults with Obesity (STEP UP) , The Lancet Diabetes & Endocrinology, 2025 [Accessed 24 April 2026] Weight Regain and Cardiometabolic Effects After Withdrawal of Semaglutide: The STEP 1 Trial Extension , Diabetes, Obesity and Metabolism, 2022 [Accessed 20 April 2026] Clinical Pharmacokinetics of Oral Semaglutide: Analyses of Data from Clinical Pharmacology Trials , Clinical Pharmacokinetics, 2021 [Accessed 20 April 2026] Wegovy 2.4 mg, FlexTouch Solution for Injection in Pre-filled Pen Summary of Product Characteristics , Electronic Medicines Compendium, 2025 [Accessed 20 April 2026] GLP-1 and dual GLP-1/GIP receptor agonists: strengthened warnings on acute pancreatitis , Medicines and Healthcare products Regulatory Agency, 2026 [Accessed 16 June 2026]
It is sometimes referred to as a lipolytic fragment of growth hormone as this part is associated with fat metabolism
Mechanistically, semaglutide monotherapy suppressed mitochondrial gene expression and elevated atrophy-related genes
